abstract：:Stem cell therapy is a promising strategy for recovering of injured cardiac tissue after acute myocardial infarction. The effects promoted by preventive physical training, beneficial for regeneration, are not yet understood on stem cell homing. In the present study, we evaluated the effect of preventive physical train...

journal_title：Cytokine

authors： Schaun MI,Kristochek M,Dias LD,Peres TR,Lehnen AM,Irigoyen MC,Markoski MM

更新日期：2020-02-01 00:00:00

abstract：:The oligoadenylate synthetase (OAS) family of enzymes are interferon-inducible antiviral proteins, which synthesize the secondary messenger 2'-5'-linked oligoadenosine (2-5A) in response to viral infection. The production of 2-5As induces RNA decay within the infected cells, thereby effectively preventing further vira...

journal_title：Cytokine

authors： Wang Y,Holleufer A,Gad HH,Hartmann R

更新日期：2020-02-01 00:00:00

abstract：:MERS-CoV, a highly pathogenic virus in humans, is associated with high morbidity and case fatality. Inflammatory responses have a significant impact on MERS-CoV pathogenesis and disease outcome. However, CD4+ T-cell induced immune responses during acute MERS-CoV infection are barely detectable, with potent inhibition ...

journal_title：Cytokine

authors： Alosaimi B,Hamed ME,Naeem A,Alsharef AA,AlQahtani SY,AlDosari KM,Alamri AA,Al-Eisa K,Khojah T,Assiri AM,Enani MA

更新日期：2020-02-01 00:00:00

abstract：AIMS:At present, there are few studies on the relationship between circulating irisin levels and gestational diabetes mellitus (GDM), and the results are inconsistent. Therefore, this study conducts a systematic review and meta-analysis to comprehensively discuss the role of irisin in the occurrence and development of ...

journal_title：Cytokine

authors： Cui L,Qiao T,Xu F,Li Z,Chen T,Su H,Chen G,Zhang L,Xu D,Zhang X

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:HIV rapid progressors (RPs) present with a rapid decline of CD4+ T cells within a few years of infection. Determining the underlying mechanisms throughout this decline is important to identify prognostic biomarkers and intervention strategies. Determining the numbers of CD4+ and CD8+ T cells is essential for...

journal_title：Cytokine

authors： Ding ZD,Zheng JF,Song CB,Fu YJ,Xu JJ,Jiang YJ,Shang H,Zhang ZN

更新日期：2020-01-01 00:00:00

abstract：:Literature studies suggest important protective effects of low-frequency, low-energy pulsed electromagnetic fields (PEMFs) on inflammatory pathways affecting joint and cerebral diseases. However, it is not clear on which bases they affect neuroprotection and the mechanism responsible is yet unknown. Therefore the aim ...

journal_title：Cytokine

authors： Merighi S,Gessi S,Bencivenni S,Battistello E,Vincenzi F,Setti S,Cadossi M,Borea PA,Cadossi R,Varani K

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVES:Little is known about the role of adipokines in the pathogenesis of coronary artery disease in young patients. The aims of this study were to compare serum levels of adipokines and expression of adipokines in peripheral blood leukocytes in patients with premature coronary artery disease (CAD), metabolic synd...

journal_title：Cytokine

authors： Smékal A,Václavík J,Stejskal D,Benešová K,Jarkovský J,Svobodová G,Richterová R,Švesták M,Táborský M

更新日期：2019-10-01 00:00:00

abstract：:The kynurenine pathway (KP) is the major metabolic route of tryptophan (Trp) metabolism. Indoleamine 2,3-dioxygenase (IDO1), the enzyme responsible for the first and rate-limiting step in the pathway, as well as other enzymes in the pathway, have been shown to be highly regulated by cytokines. Hence, the KP has been i...

journal_title：Cytokine

authors： Baumgartner R,Forteza MJ,Ketelhuth DFJ

更新日期：2019-10-01 00:00:00

abstract：:Metabolic syndrome poses a major threat on human health affecting the quality of life. Adipose tissue is an important organ which plays a crucial role in the pathogenesis of metabolic syndrome. Adipocytokines secreted by the adipose tissue plays a critical role in storage, food intake, energy expenditure, lipid and gl...

journal_title：Cytokine

authors： Ghadge AA,Khaire AA

更新日期：2019-09-01 00:00:00

abstract：:Ureaplasma species (spp.) are considered commensals of the adult urogenital tract, but may cause chorioamnionitis and preterm birth as well as sepsis and meningitis in neonates. Pathomechanisms in Ureaplasma-driven neuroinflammation are largely unknown. This study addressed mRNA and protein expression of intercellular...

journal_title：Cytokine

authors： Silwedel C,Speer CP,Haarmann A,Fehrholz M,Claus H,Schlegel N,Glaser K

更新日期：2019-09-01 00:00:00

abstract：:Thymic vulnerability, a leading cause of defective immunity, was discovered decades ago. To date, several strategies have been investigated to unveil any immunorestorative capacities they might confer. Studies exploiting castration, transplantation, adoptive cell therapies, hormones/growth factors, and cytokines have ...

journal_title：Cytokine

authors： El-Kadiry AE,Rafei M

更新日期：2019-08-01 00:00:00

abstract：:Following recent attention focused on IL-32 as an important component involved in the inflammatory cytokine network, we speculated that IL-32's action on IFN-γ and IFN-γ secreting T cell subsets may help sustain the immune activation and dysregulation found in patients with HIV-1 achieving viral suppression. To explor...

journal_title：Cytokine

authors： Santinelli L,Statzu M,Pierangeli A,Frasca F,Bressan A,Pinacchio C,Nonne C,Turriziani O,Antonelli G,d'Ettorre G,Scagnolari C

更新日期：2019-08-01 00:00:00

abstract：:Angiopoietin-like proteins (ANGPTL) are responsible for inhibiting lipoprotein lipase activity, and ANGPTL3 and ANGPTL4 deficiencies have been shown to lower lipoprotein levels in animal models and in humans carrying loss-of-function mutations. Sickle cell anemia (SCA) is a hereditary hemolytic anemia characterized by...

journal_title：Cytokine

authors： Vendrame F,Olops L,Saad STO,Costa FF,Fertrin KY

更新日期：2019-08-01 00:00:00

abstract：INTRODUCTION:Patients with chronic kidney disease (CKD) have a high risk of death mainly due to cardiovascular diseases (CVD). Early risk identification may allow interventions and prevention of fatal events. OBJECTIVES:The study aim was to assess the usefulness of selected CVD biomarkers as predictors of 5-year morta...

journal_title：Cytokine

authors： Kamińska J,Stopiński M,Mucha K,Jędrzejczak A,Gołębiowski M,Niewczas MA,Pączek L,Foroncewicz B

更新日期：2019-08-01 00:00:00

abstract：:The possibility has been suggested that interferon (IFN)-λs can be induced rapidly for restricting respiratory viral infection in asthmatic mice and may modulate Th2-related immune responses that underlie the pathogenesis of asthma. We sought to determine the in vivo contribution of IFN-λs on decrease of Th2 cytokines...

journal_title：Cytokine

authors： Won J,Gil CH,Jo A,Kim HJ

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Granulocyte colony-stimulating factor (G-CSF) is the standard-of-care therapy for chemotherapy-associated neutropenia in patients with malignancies. Recent case reports have implied that G-CSF treatment may be associated with the development of aortitis, but the precise nature of the relationship is unclear....

journal_title：Cytokine

authors： Oshima Y,Takahashi S,Tani K,Tojo A

更新日期：2019-07-01 00:00:00

abstract：:The present study aimed to assess the kinetics of cytokine release and compare the accuracy of serum biomarkers for the diagnosis of macrophage activation syndrome (MAS) associated with Kawasaki disease (KD). Serum neopterin, interleukin (IL)-18, IL-6 and soluble tumour necrosis factor receptor type I (sTNFR-I) and sT...

journal_title：Cytokine

authors： Jinkawa A,Shimizu M,Nishida K,Kaneko S,Usami M,Sakumura N,Irabu H,Takakuwa M,Inoue N,Mizuta M,Ikawa Y,Fujita S,Yachie A

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:Omentin-1, an anti-inflammatory protein, is secreted by the visceral adipose tissue. Altered levels of Omentin-1 are associated with obesity and Type 2 Diabetes (T2D). Although Omentin-1 is implicated in the insulin signaling pathway, the relationship between the genetic variants of Omentin-1 and T2D is not y...

journal_title：Cytokine

authors： Rathwa N,Patel R,Pramanik Palit S,Jadeja SD,Narwaria M,Ramachandran AV,Begum R

更新日期：2019-07-01 00:00:00

abstract：:Proteolytic activation of the IL-33 precursor, full-length interleukin-33 (FLIL33), at multiple sites within the sensor domain (aa 95-109) yields several functionally mature (MIL33) forms. Unlike nuclear FLIL33, intracellular MIL33 occurs in the cytoplasm, is secreted from source cells, and exerts biological effects b...

journal_title：Cytokine

authors： Luzina IG,Clerman A,Fishelevich R,Todd NW,Lockatell V,Atamas SP

更新日期：2019-07-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a fast-growing cancer characterized by high occurrences of nodal and distant metastases and poor prognosis. It is therefore important to identify new serum biomarkers for the early diagnosis and prognostic prediction of this disease. The present study identifies biomarkers in NPC pati...

journal_title：Cytokine

authors： Gong D,Li Z,Ding R,Cheng M,Huang H,Liu A,Kang M,He H,Xu Y,Shao J,Wang Y,Duan C

更新日期：2019-06-01 00:00:00

abstract：:Interleukin (IL)-7 stimulation improves virus- and tumor-specific CD8+ T cell responses. However, the role of IL-7 in modulation of dysfunctional CD8+ T cells in hepatocellular carcinoma (HCC) was not completely understood. In this study, a total of 37 HLA-A2 restricted patients with HCC and 16 healthy individuals wer...

journal_title：Cytokine

authors： Teng D,Ding L,Cai B,Luo Q,Wang H

更新日期：2019-06-01 00:00:00

abstract：:Among myriads of distinct chemical modification in RNAs, the dynamic, reversible and fine-tuned methylation of N6-methyladenosine (m6A) is the most prevalent modification in eukaryotic mRNAs. This RNA mark is generated by proteins that act as m6A writers and can be reversed by proteins that act as m6A erasers. The RNA...

journal_title：Cytokine

authors： Chang G,Leu JS,Ma L,Xie K,Huang S

更新日期：2019-06-01 00:00:00

abstract：AIMS:There is interest in using blood C-reactive protein (CRP) to predict adverse prognosis outcomes patients with type 2 diabetes. This meta-analysis aimed to investigate the association between elevated baseline CRP level and unfavorable outcomes in type 2 diabetes patients. MATERIALS/METHODS:PubMed and Embase datab...

journal_title：Cytokine

authors： Tian R,Tian M,Wang L,Qian H,Zhang S,Pang H,Liu Z,Fang L,Shen Z

更新日期：2019-05-01 00:00:00

abstract：:The γc family of cytokines comprising interleukin-2 (IL-2), IL-4, IL-7, IL-9, IL-15 and IL-2 is an important group of 4-helix bundle cytokines that signals through receptors incorporating the common gamma chain (γc). These cytokines are involved in lymphocyte biology and their specific functions are contingent on bind...

journal_title：Cytokine

authors： Reche PA

更新日期：2019-04-01 00:00:00

abstract：:Inhibition of inflammation is one of the possible therapeutic approaches for Insulin resistance (IR) during type 2 diabetes mellitus (T2DM). In the current study we investigated the effects of palmitate and chicoric acid (CA) on inflammation in peripheral blood mononuclear cells (PBMCs) of newly diagnosed T2DM patient...

journal_title：Cytokine

authors： Sadeghabadi ZA,Ziamajidi N,Abbasalipourkabir R,Mohseni R,Borzouei S

更新日期：2019-04-01 00:00:00

abstract：:The aim of this study was to evaluate serum interleukin (IL)-17A levels in patients with coronary artery ectasia (CAE), the relationship between IL and 17A and CAE, and to determine the relationship between the severity of coronary ectasia and the level of IL-17A. In total, 41 patients (19 female and 22 male) with isc...

journal_title：Cytokine

authors： Uygun T,Demir B,Tosun V,Ungan İ,Kural A,Çiftçi R,Fatullayev F

更新日期：2019-03-01 00:00:00

abstract：:There appears to be an associative link between chronic hepatitis C (CHC) and cardiovascular diseases (CVDs). However, the exact nature of the relationship between CHC and CVDs has not been elucidated. We investigated the presence of CVDs and the clinical and laboratory alterations associated with these diseases in CH...

journal_title：Cytokine

authors： Santos TPS,Pereira MM,Schinoni MI,Sampaio GP,Aras R Jr,Atta MLS,Atta AM

更新日期：2019-03-01 00:00:00

abstract：INTRODUCTION:Resveratrol has been reported to alleviate inflammatory responses and oxidative stress in mesangial cells and in several types of renal injury in animal models. Previously, the active resveratrol derivatives from the roots of Vitis thunbergii Sieb. & Zucc. (Vitaceae) were shown to have significant anti-pla...

journal_title：Cytokine

authors： Lee IT,Lin CF,Huang YL,Chong KY,Hsieh MF,Huang TH,Cheng CY

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION:A growing body of evidence indicates that brain cytokines are involved in the control of the cardiovascular system. Tumour necrosis factor (TNF) is an archetypal cytokine, which exerts its proinflammatory actions via type 1 receptor (TNFR1). Interleukin 10 (IL-10) plays a critical anti-inflammatory role by...

journal_title：Cytokine

authors： Segiet A,Smykiewicz P,Kwiatkowski P,Żera T

更新日期：2019-01-01 00:00:00

abstract：:Neuregulin-4 (Nrg4) is a novel adipokine associated with obesity, hyperglycemia, insulin resistance, dislipidemia, inflammation, and oxidative stress in mice and humans. However, no report has demonstrated the relationship of circulating Nrg4 with diabetic peripheral neuropathy (DPN). The objective of our study was to...

journal_title：Cytokine

authors： Yan P,Xu Y,Zhang Z,Gao C,Zhu J,Li H,Wan Q

更新日期：2019-01-01 00:00:00

abstract：:Human interferon regulatory factor 7 (IRF7) plays an important role in the innate antiviral immune response. To date, the characteristics and functions of waterfowl IRF7 have not been clarified. This study reports the cDNA sequence, tissue distribution, and antiviral function of duck IRF7. The duck IRF7 gene has a 153...

journal_title：Cytokine

authors： Chen S,Wang T,Liu P,Yang C,Wang M,Jia R,Zhu D,Liu M,Yang Q,Wu Y,Zhao X,Cheng A

更新日期：2019-01-01 00:00:00

abstract：:Type I interferonopathies are characterized by an increase of circulating type I interferon (IFN) concentration. Type I interferonopathies refer to rare Mendelian genetic disorders such as Aicardi-Goutières Syndrome (AGS) as well as more frequent and polygenic auto-immune diseases like systemic lupus erythematosus (SL...

journal_title：Cytokine

authors： Pescarmona R,Belot A,Villard M,Besson L,Lopez J,Mosnier I,Mathieu AL,Lombard C,Garnier L,Frachette C,Walzer T,Viel S

更新日期：2019-01-01 00:00:00

abstract：:Pregnancy in sickle cell disease is a problem due to the adverse outcomes related to the disease. Research into the role of chemokines in sickle cell disease is available, but studies investigating the disease in pregnancy are scarce. Our data show the chemokine profiles of pregnant women with sickle cell disease comp...

journal_title：Cytokine

authors： Hazin-Costa MF,da Silva Aráujo A,Guerra GL,da Matta MC,Torres LC,Souza AI

更新日期：2019-01-01 00:00:00

abstract：:Adiponectin, the most prevalent adipo-cytokine in plasma plays critical metabolic and anti-inflammatory roles is fast emerging as an important molecular target for the treatment of metabolic disorders. Adiponectin action is critical in multiple organs including cardio-vascular system, muscle, liver, adipose tissue, br...

journal_title：Cytokine

authors： Pal China S,Sanyal S,Chattopadhyay N

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:Functions of the Th9 cells and its signature cytokine IL-9 in human autoimmune diseases is currently under extensive research. Here we are reporting new functions of IL-9-receptor (IL-9R); its regulatory role on (i) FLS (fibroblast like synoviocyte) biology and (ii) pannus formation in rheumatoid arthritis (R...

journal_title：Cytokine

authors： Raychaudhuri SK,Abria C,Maverakis EM,Raychaudhuri SP

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:IL-10 family cytokines are associated with the host immune response to pulmonary tuberculosis (PTB), but their association with host response in tuberculous lymphadenitis (TBL) is not known. METHODS:Hence, we examined the circulating levels of the whole panel of IL-10 family cytokines in TBL (n = 44) and co...

journal_title：Cytokine

authors： Kathamuthu GR,Kumar NP,Moideen K,Baskaran D,Hissar S,Shrinivasa BM,Sridhar R,Babu S

更新日期：2018-11-01 00:00:00

abstract：:Kawasaki disease is a multi-system vasculitis and a primary cause of acquired heart disease among children. Genetic factors may increase susceptibility to Kawasaki disease. TBXA2R is a G-protein-coupled receptor that participates in tissue inflammation and is associated with susceptibility to several diseases, but its...

journal_title：Cytokine

authors： Che D,Pi L,Xu Y,Fu L,Zhou H,Wang Z,Huang P,Zhang L,Gu X

更新日期：2018-11-01 00:00:00

abstract：:Endothelial barrier dysfunction leads to increased endothelial permeability and is an early step in the development of vascular inflammatory diseases such as atherosclerosis. Interferon-γ (IFN-γ), a proinflammatory cytokine, is known to cause increased endothelial permeability. However, the mechanisms by which IFN-γ d...

journal_title：Cytokine

authors： Ng CT,Fong LY,Yong YK,Hakim MN,Ahmad Z

更新日期：2018-11-01 00:00:00

abstract：:HIV infection is associated with chronic inflammation in both non-treated and treated patients. TLR-dependent mechanisms are strongly involved in the maintenance of this inflammation. Indeed, the residual replication of HIV, the potential viral co-infections, or the products issued from microbial translocation provide...

journal_title：Cytokine

authors： Leite Pereira A,Tchitchek N,Marcos Lopez E,Lambotte O,Le Grand R,Cosma A

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Unregulated inflammatory and thrombotic responses have been proposed to be important causes of early brain injury and worse clinical outcomes after subarachnoid hemorrhage (SAH). OBJECTIVE:We hypothesize that SAH is characterized by an increased inflammatory and thrombotic state and disruption of associatio...

journal_title：Cytokine

authors： Savarraj JP,McGuire MF,Parsha K,Hergenroeder G,Bajgur S,Ahn S,Zhu L,Espino E,Chang T,Blackburn S,Kim DH,Dash P,Choi HA

更新日期：2018-11-01 00:00:00